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[DOI] [PMC free article] [PubMed] [Google Scholar] 26.European Association for the Study of the Liver (EASL) European Association for the Study of Diabetes (EASD) European Association for the Study of Obesity (EASO) EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD) J

In our opinion, combination therapies taking advantage of SAMes ability to enhance chemosensitivity and modulate epigenetic status will be the most promising, as SAMe combined with decitabine or doxorubicin in targeting breast cancer, with cisplatin in head and neck squamous cancer, or even sensitizing cancer cells to radiotherapy [146,254,255,257,258]

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A reliable biomarker of oxidative stress must fulfill the following criteria: (a) clinical relevance (b) specificity for certain diseases (c) reflect the stage of the disease (d) quantification of the biomarkers should show a high degree of reproducibility

Studies have shown that liposomes modified with the transferrin receptor antibody OX26 can activate receptor-mediated transcytosis, significantly improving the ability of drugs to cross the bloodbrain barrier, thereby achieving sustained therapeutic effects in PD rat models (Xia et al., 2008)