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The most significant indicator of degradation is a lack of expected results in your research

Proc Natl Acad Sci USA 1997
Taking into account that reactive astrocytes may produce various neurotrophic factors and antioxidant molecules targeting neuronal survival, it is possible that genetic manipulation of these functions in astrocytes may represent a promising strategy to improve dopaminergic neurons or neural progenitor cells survival [4,23]

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Experiments with purified GSTs have not been reported, but the mechanism involving the sulfur of glutathione (see below) could be expected to show proton exchange with the solvent
Nutritional and functional importance of intestinal sulfur amino acid metabolism
