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Description
All of the studies used both in vivo and some form of in vitro methods of data collection in order to observe different treatment effects, allowing for biomechanical, functional (use of AFI index and load to failure), macroscopic and microscopic histological analysis

Given their non-invasive nature and similar clinical performance, these routes may represent suitable alternatives to intramuscular therapy, particularly in settings requiring long-term management

In patients with prolonged, persistent symptoms, the host immune response may become dysregulated through inflammatory or secondary autoimmune pathways, or non-specific immune activation

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