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Expanded view Figure EV1 Enriched genes and pathways in CoQ deficient murine brown adipocytes

One provides a concentrated dose, while another is more sparingly dosed

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Indeed, splenocyte incubation with lysoPC, a circulating bioavailable form of PC, enhances proliferation and IL-2 secretion (48), suggesting that PC positively modulates T-cell function and may counteract immune dysfunction

The relevance of recognising this disorder lies in the reversibility of hyperammonaemia and prevention of permanent neurological damage and death.4 Genetic counselling of all relatives is mandatory

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