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PubMed World Anti-Doping Agency
doi:10.1159/000053183 Wilding JPH, Batterham RL, Calanna S, et al

No human study has tested these combinations

This population-specific safety evidence is more relevant for clinical application than data from exclusively healthy volunteers would be

In 2009, the EMEA (European Medicine Agency) withdrew market authorisation for rimonabant in all countries of the European Union due to safety concerns [21]

For individuals with BMI above 30 or BMI above 27 with comorbidities, FDA-approved GLP-1 receptor agonists (semaglutide, tirzepatide) have far stronger evidence and produce dramatically greater weight loss
