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Abstract Within the consistent daily rhythm of human life, intervertebral discs endure a variety of complex loads beyond the influences of gravity and muscle forces, leading to significant morphological changes (in terms of volume, area, and height) as well as biomechanical alterations, including an increase in disc stiffness and a decrease in intradiscal pressure

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Particle & Particle Systems Characterization , 36

Byproducts of lipid peroxidation, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), directly modify renal cellular proteins, impairing autophagy and promoting tubular interstitial fibrosis (40)

Furthermore, melatonin may be beneficial for metabolic syndrome in patients treated with antipsychotics [99]

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