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Miller JW (2018) Proton Pump inhibitors, H2-Receptor antagonists, Metformin, and vitamin B12 Deficiency: clinical implications

Exposing infant rats during early postnatal life to stress altered the methylation status and the expression of the brain-derived neurotrophic factor Bdnf gene in the adult prefrontal cortex

This decision follows a comprehensive review of data demonstrating that when BHRT is initiated during the "therapeutic window", typically within 10 years of menopause onset or before age 60, the benefits for symptom relief, bone density preservation, and cardiovascular protection often outweigh the risks

Radiat Oncol (2015) 10:145

71 The likelihood that there may be a genetic perspective in the deficiency of vitamin B 12 induced by metformin has been explored by one group with polymorphisms in genes such as methylene tetrahydrofolate reductase (MTHFR) suggested as possible candidates

Accordingly, the optimal strategy should be regarded as a biomarker-specific, application-driven selection
