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A large number of research groups in pharmaceutical companies and academic institutions have used targeted synthesis of potential SEGRAs activating selectively GR TR but not GR TA

Excess intracellular free Fe 2+ facilitates the reduction of oxygen, generating superoxide radicals, and causes lipid peroxides through Fenton reactions, resulting in ferroptosis finally (Liu K

In addition to SOD-mimetic compounds, Salen-based organic compounds, possessing hydrogen peroxide scavenging activity have been prepared and tested as Glutathione peroxidase mimetics

Dysregulated iron homeostasis constitutes the fundamental basis for ferroptosis initiation (59)

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