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Your Overall Health Underlying health conditions, such as gastrointestinal disorders (like Crohns disease, celiac disease, or atrophic gastritis) that impair nutrient absorption, or certain medications you may be taking, can influence how your body absorbs and utilizes B12

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Patients with nerve-related symptoms, such as tingling or memory lapses, may benefit from its direct bioavailability

In fact, a study looking at the Pfcrt changes over a 13 year period between 1993 and 2006 in Kilifi, Kenya found that the 76T mutation only decreased from 94% to 63% [38]