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There is also the case of addictive drugs: for example, cocaine is known to decrease the livers GSH content and has been found to be conjugated with GSH, highlighting that cocaine impairment of protein thiols can be a molecular mechanism of its toxicity [139]
Tetrahedron 19, 20732078
DuZLiFJiangLLiLDuYYuHet al
Additionally, Verapamil has been shown to reduce bacterial persistence, a major challenge in TB treatment, by enhancing drug accumulation and immune-mediated clearance [84]
SGLT2 inhibitors (SGLT2i) provides nephroprotective benefits in to human patients with DKD, presumably by suppressing HIF1A and stimulating HIF2A, which in turn augments erythropoiesis 44,45,46,47
doi: 10.1104/pp.17.00622 110 SinghJ.ThakurJ
