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In addition, by feeding quantitative data of bismuth absorption by HK-2 to the SAPT model, we deduce that GSH biosynthesis will be activated after bismuth saturation at 36 h, after which the GSH levels were greatly elevated ( in vivo and in vitro and the timing of the upregulation of GSH levels found in vitro and in silico agree with each other (Figure 4D) (Morikawa et al., 1990)

doi: 10.1093/schbul/sbac065

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Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin-induced cardiotoxicity

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