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In contrast, ALP has garnered considerable attention as a reporter enzyme for signal amplification due to its outstanding advantages of high catalytic activity, high turnover number, and broad substrate specificity [35,36,37]

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Additionally, when combined with B6 and folate, B12 has been shown to enhance blood-brain barrier function in patients experiencing mild cognitive impairment

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Future investigations should refine therapy parameters, explore optimal timing and duration, validate their efficacy in diverse patient populations, and conduct comparative studies against conventional treatments