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Foretinib is a class II inhibitor targeting c-MET, VEGFR2, Recepteurd Origine Nantais (RON), kinase insert domain receptor (KDR), and Fms related tyrosine kinase 1 (Flt-1) with potent inhibition of c-MET kinase activity (enzymatic IC50 1.16 nM) [100]

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The proposed mechanism described in papers that were later retracted is that it potentiates hepatocyte growth factor (HGF) signaling at the c-Met receptor, driving dendritic spine formation and synaptogenesis

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