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Nicotinamide-N-methyltransferase gene rs694539 variant and migraine risk

VPS35 in dopamine neurons is required for endosome-to-golgi retrieval of Lamp2a, a receptor of chaperone-mediated autophagy that is critical for alpha-synuclein degradation and prevention of pathogenesis of Parkinson's disease

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Additionally, age-associated declines in cerebral blood flow and increased bloodbrain barrier permeability further compromise glymphatic transport, allowing inflammatory mediators and ROS to accumulate in the brain parenchyma (Xiong et al., 2024)

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