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Uchida, H

Lung tissue and sample preparation In each group, the left lungs of 6 mice were infused with 0.5 ml PBS three times for the harvest of bronchoalveolar lavage (BAL) fluid, while the left lung tissues of the other 6 mice were inflated with 10% neutral formaldehyde at positive pressure (25 cm H 2 O) ( Histology The paraffin sections (4 m) were stained with hematoxylin and eosin (H&E)

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These findings suggest that liver disease may exacerbate AD pathology through two mechanisms: diminished peripheral clearance capacity and increased production of pathogenic proteins due to liver dysfunction

Notably, c-MET is initially expressed as a 150 kDa single-chain precursor, which then turns into the mature form through the proteolytic cleavage between Arg307 and Ser308 by the furin protease 8