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Excessively consuming such diets not only directly affects energy metabolism in liver, but also increases the concentration of TMAO in plasma, which promotes the development of MAFLD by affecting bile acid metabolism, unfolded protein response, and oxidative stress

That situation normal or high serum B12 with elevated MMA is what researchers now call functional B12 deficiency, and it is far more common than most clinicians recognize

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Moreover, the albumin-based NPs can also cross the BBB and reach tumor cells by SPRAC (secreted protein acidic and rich in cysteine) and gp 60 (glycoprotein 60) mechanisms-mediated targeting [237]

Therefore, for patients with NAFLD, especially those with a restricted diet (e.g., meat) [42], it is safe to supplement with L-carnitine

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