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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

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7,1922 Many of these medications require dosing adjustment in older patients and in those with reduced creatinine clearance

[1] [2] [7] Deficiency can also be caused by inadequate dietary intake such as with the diets of vegetarians, and vegans, and in the malnourished

This makes supplementation especially important for vegetarians, older adults, and those with digestive disorders or a history of GI surgery

Here are some dog-friendly foods containing B12: Meat and poultry: Ensure your dog's diet includes good sources of animal protein like beef, chicken, turkey, and lamb