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The link with lipid metabolism has been provided by employing a siRNA for OCTN2, which lowered carnitine uptake triggering an increased formation of lipid droplets and a decreased cell proliferation

This was the first demonstration that apoptotic stimuli lead to the proteolytic cleavage of a PKC

Huidong Guo, Xiaojun Chen, Rong Li, Jianzhen Shen, Donghui Gan, Yue Yin, Hehui Zhang, Jiachen Xie, Longfei Xie, Yanquan Liu Journal of Hepatocellular Carcinoma .2025

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Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1/CIP1) and C/EBPbeta expressions and suppressing NF-kappaB activation