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From these results, it could be inferred that CaOx-induced ferroptosis, as observed in the previous series of biochemical reactions, reduced the ability of cells to resist oxidation, thereby resulting in Fe2+ overload, mitochondrial damage and an increase in lipid peroxidation, which then induced an intracellular ROS outbreak, eventually causing severe cell injury

Xue et al., 2004a
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In UK practice, monitoring is primarily based on clinical response rather than routine blood tests, as post-treatment serum B12 measurements can be misleadingly high and may not reflect tissue levels
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