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A first study, as mentioned before, demonstrates that GSH1 from Nicotiana tabacum forms an active homodimer under oxidizing conditions [43]

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10.1111/j.1471-4159.1990.tb02325.x J

Inhibition of Nrf2 expression or activity can increase the sensitivity of tumors to anticancer drugs [87]

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Additionally, mitochondrial ROS-induced oxidation of GSDMD is a crucial mechanism facilitating GSDMD cleavage, which in turn drives NLRP3-dependent pyroptosis in macrophage [144]
