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doi: 10.1016/j.tics.2005.10.005

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B cell activity is impaired in human and mouse obesity and is responsive to an essential fatty acid upon murine influenza infection

Beyond this direct scavenging activity, GSH serves as an essential cofactor for several families of antioxidant and detoxification enzymes, including glutathione peroxidases (GPx) and glutathione S-transferases (GSTs)

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In mammals, the first reaction of the de novo GSH synthesis pathway is catalyzed by glutamate cysteine ligase (GCL), also known as -glutamylcysteine synthetase (GCS), which contains all the substrate and cofactor binding sites to produce -glutamylcysteine (-GC) [64]