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RESULTS Time-Course of CIA in DBA/1J Mice The development of inflammation was assessed by scoring the clinical disease activity and measuring changes in paw volumes

To examine the dynamics of cortical demyelination, we used longitudinal in vivo two-photon imaging of V1 in Mobp-EGFP mice (Fig

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Research interest in the AngIV/AT4 receptor system was further encouraged by the finding that AT1 and AT2 receptor antagonists failed to block learning and memory tasks in animal models [70]

The mechanisms studied in animal models include growing new blood vessels (angiogenesis, via VEGFR2), helping repair cells move to the injury (fibroblast migration, via the FAK-paxillin pathway), and supporting blood flow through the nitric-oxide pathway

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