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The release of Nrf2 allows its translocation into the nucleus to activate various promoter regions responsible for antioxidant system activation (Figure 3) [49]

Evaluations of fatigue and cognitive function are intrinsically related, and the neuropsychological examination seems to be a valuable resource to properly assess fatigue, cognitive impairment, and psychological-driven complaints

The risk of developing RLS is also highest in the elderly (Yeh et al., 2012).Most researchers added to their inclusion criteria a minimal IRLSRS score at baseline, generally including participants with a moderate to severe condition (Guay et al., 2020)

Loss of SIRT1 function in rats is due to overall follicle activation 76

Studies have shown that CoQ10-containing preparations may show different bioavailability depending on the formulation used