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The toxicokinetics of APAP can be altered by genetics, dose, diet, age, alcohol and other factors, and these factors make translating biomarkers discovered in omics nonclinical studies to the clinic challenging

High GGT levels may suggest liver damage, which can result from alcohol abuse, certain medications, fatty liver disease, hepatitis, or bile duct blockage

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executive dysfunction, which can include problems with planning, cognitive flexibility, abstract thinking, rule acquisition, initiating appropriate actions and inhibiting inappropriate actions, and selecting relevant sensoiy information, fluctuations in attention and slowed cognitive speed, memory (especially in recalling learned information), visuospatial difficulties e.g