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By screening in four different media conditions, we uncovered their metabolic regulation, including the fitness defects in the mitochondrial folate transporter SLC25A32 KO cells that can be buffered in galactose condition due to substrate limitation in de novo purine biosynthesis

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With this early rescue dose, the patient likely survives because the dashed black curve in Panel B stays well above the 30% level for functional hepatocytes, which is thought to indicate liver failure

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Les souris dpourvues de GCLM ne prsentent pas de phnotype, mais prsentent une diminution marque du GSH et une sensibilit accrue la toxicit