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When applied directly to the skin, it can reduce inflammation and temporarily relieve minor skin irritations, itching, and rashes by reducing the secretion of histamine, a compound produced by cells of the immune system in response to the presence of pathogens or other foreign substances

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doi: 10.1523/JNEUROSCI.1098-11.2011

The behavior exhibited by animals in self-administration experiments is similar to that of drug addicts, and data on characterized behavior patterns such as increases and decreases in lever pressing under certain conditions are used to investigate the mechanisms of physical and psychological dependence 15,16

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