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The excessive production of ROS has been detected in many settings of alveolar bone injuries, including periodontitis, implant osseointegration and orthodontics-related bone loss

Additionally, due to the stimulation by CaOx crystals, mitochondrial function is impaired and cannot exert antioxidant capabilities, leading to the accumulation of ROS within cells, ultimately inducing ferroptosis

Suzuki T, Motohashi H, Yamamoto M (2013) Toward clinical application of the Keap1-Nrf2 pathway

doi: 10.1016/j.cell.2013.12.010 182 ZhuSZhangQSunXZehHJ3rdLotzeMTKangRet al

[DOI] [PubMed] [Google Scholar] 224.Pferschy-Wenzig E
10.1016/j.gde.2010.10.005 Curr