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"Topical and oral supplementation of glutathione and vitamin C improves skin health by reducing inflammation and oxidative stress," Dermatologic Therapy, 2018

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Biol Trace Elem Res 2017;176:5663

Oxygen radicals insert into the C-H bonds of PUFAs, generating lipid hydroperoxides and elevating levels of ROS, which induce ferroptosis (55)

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Importantly, FOXO4-DRI achieves these effects with favorable treatment kinetics compared to approved medications like pirfenidone, suggesting potential for more efficient therapeutic intervention