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Follow these instructions closely, as they help patients reduce the risk of complications

doi: 10.3389/fimmu.2025.1643017 Received 07 June 2025 Accepted 31 August 2025 Published 17 September 2025 Volume 16 - 2025 Edited by Hai Fang, Shanghai Jiao Tong University, China Reviewed by Zhi Li, Shanghai University of Traditional Chinese Medicine, China Xinmei Dong, BeiGene, China Updates Copyright 2025 Du, Xiao, Guojun, Dai, Li, Zhao, Zhang, Yang, Liu, Hu, Wen, Zhou, Dai, Zhang and Zhang

Acknowledgements We thank Professors Brenda Schulman and Danny Nedialkova at MPIB for reagents, and Sabine Suppmann and the MPIB Protein Production Core Facility for LIF

Glutathione is a small protein molecule composed of 3 amino acids: cysteine, glutamate, and glycine called Glutathione precursors or building blocks

Hydroxyl radicals are extremely reactive, cannot be scavenged by enzymatic reaction, and have a diffusion controlled half-life of ~10 9 s before reacting with organic molecules in vivo (Freinbichler et al., 1993

Accordingly, it comprised 2394 metabolite ions and 65,303 corresponding isotopologues following the administration of U- 13 C glucose and 928 metabolite ions with 27,458 corresponding isotopologues after the administration of U- 13 C glutamine (Supplementary Data 2)