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Evidence that behavioral phenotypes of morphine in beta-arr2-/- mice are due to the unmasking of JNK signaling

10.1016/s0092-8674(00)80783-7 Cell 28 DoetschF.Garcia-VerdugoJ

In both Cagri- and rAmy-bound AMY 1 R structures, F83 RAMP1 packs over R126 ECD stabilising the same interface of the RAMP1-CTR ECD when bound by both peptides 15
doi: 10.1038/s41571-022-00668-4 [DOI] [PMC free article] [PubMed] [Google Scholar] 35.Imb M, Vghelyi Z, Maurer M, Khnel H

Phosphoinositide 3-kinase delta (PI3K) in leukocyte signaling and function

However, it remains unapproved for general medical use, and its long-term effects are still under investigation
