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The endogenous thiols GSH and thioredoxin (TRX) systems play indeed a central role in the antioxidant defenses that control cellular events and regulate protection against oxidative stress, that alters normal redox control of cellular signaling, especially by disruption of thiol-redox circuits

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The current primary use of inhaled drugs is to exhibit a local effect on the lung tissue by binding to receptors on the bronchial smooth muscle in cases of bronchoconstriction

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