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It is also widely established that DNA can be altered by prolonged exposure to high ROS levels and that oxidative DNA damage has a distinct catalog of somatic mutations in cancer (COSMIC) mutation signature (Rose Li et al., 2020)
Expert Rev Clin Pharmacol 12(10):981989 Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE (2012) Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
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Emerging evidence has identified additional oxidative mechanisms contributing to DKD progression
