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Some of the possible factors that are abundant in CS are polyaromatic hydrocarbons (PAHs) that are inducers of cytochrome P450s and are well known sources of reactive oxygen species [28]

The authors reported an increased Firmicutes/Bacteroidetes ratio and Streptococcus abundance, with a reduction in Prevotella strains in patients with active MS when compared with healthy controls and patients with MS in remission ( Prevotella strains was inversely associated with Th17 cells in the small intestine, while positively related to disease activity ( 2.4.3 Treatment strategies 2.4.3.1 Probiotics Synergistic therapeutic effects may be exerted by the different strains in probiotic cocktails

Identification of Ribosomal Protein S4, Y-linked 1 as a cyclosporin a plus corticosteroid resistance gene

Both encode a mitochondrial GLS, which catalyzes the hydrolysis of glutamine to glutamate [45, 46]

However, the direct evidences to verify BA activated brain FXR signaling in regulating brain function still need to be further explored