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Cytokine release syndrome (CRS) was avoided by using an IgG4 isotype, which does not activate complement fixation (67)

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Complementary preclinical angiogenesis models may include the chick chorioallantoic membrane assay, rodent Matrigel plug assays conducted under approved laboratory animal research protocols, and other standardized tissue-level models

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Winter HK, Ehrlich VA, Grusch M et al (2008) Use of four new human-derived liver-cell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay