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A thorough risk assessment of tumorigenic potential, including uncontrolled growth and malignant transformation, is mandatory before clinical translation

doi: 10.1007/s00125-003-1097-5

Adam Cook 2

Considering the high intracellular concentrations, GSH acts as a potent antioxidant against a variety of ROS, while GSH depletion is caused by increased oxidative stress and/or decreased GSH synthesis, especially in neurons, which are more vulnerable to ROS than are glial cells [5]

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This provides direct evidence linking ferroptosis to the regulation of lipid metabolism