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The expansion of available therapies not only helps meet the growing demand for effective treatment but also provides better patient outcomes

A general increase in ROS and free radicals in the aged brain and a phenomenon known as niche stiffening of the extracellular matrix (ECM) directly adjacent to OPCs can also prevent their differentiation (French et al., 2009

We confirmed that several PERK inhibitors (GSK, GSK2656157, and AMG-PERK) or HSP90 inhibitors (luminespib and 17-AAG) enhance MZ1-induced degradation of endogenous BRD4 or BRD2 (Fig

The greatest disadvantage of BPC-157 is that it lacks adequate evidence of safety