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Cancer Treat Rev 66:95-103, 2018

Healthy cells maintain glutathione concentrations between 0.5 and 10 millimolar, with about 95% of the cell's non-protein thiol groups composed of glutathione, ensuring it is well-prepared for both its antioxidant and recycling roles [12]

184,185 Upregulated USP20 expression in oxaliplatin-resistant HCC cells is associated with poor prognosis, while genetic knockdown or pharmacological inhibition of USP20 can trigger ferroptosis and increase the sensitivity of HCC cells to oxaliplatin both in vitro and in vivo

Cell 152 (5), 11061118

( A ) Scatterplot for the relationship between NRF2 dependence, defined by a negative Chronos Score for NFE2L2 , and NRF2 activation, calculated based on the variance of mRNA expression of 9 canonical NRF2 target genes, across 973 cancer cell lines from the Cancer Dependency Map

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