role of glutathione as antioxidant Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Glutathione Participation in the Prevention

Attenuation of ischemic injury by N-acetylcysteine preconditioning of the liver

The synthesis of aspartate kinase (AK), which catalyzes the phosphorylation of aspartate and initiates its conversion into other amino acids, is feed-back inhibited by lysine, isoleucine, and threonine, which prevents the synthesis of the amino acids derived from aspartate

D.GoncalvesC

10.1038/nature09852 Nature 218 OjhaR.JhaV.SinghS

These changes suggest that the absence of Nrf2 not only diminishes the hosts antioxidant defenses but also weakens intestinal immune function, impairing its ability to control harmful gut bacteria

Group 3: pristane - treated animals were treated intravenously with glutathione in a dose of 5 mg/kg daily for 30 days [14]