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FIGURE 1 2.1 Orchestrating the non-immune cells in the tumor microenvironment with peptides 2.1.1 Peptide mediation in cancer-associated fibroblast-induced extracellular matrix remodeling Cancer cells recruit CAFs, which are crucial in shaping the malignant TME

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the blocking of 2 adrenergic action in the splanchnic vasculature allows unopposed adrenergic action, causing splanchnic vasoconstriction, and hence reduced portal inflow including that from collateral vessels by about 15%

doi: 10.1038/nature08182 [DOI] [PubMed] [Google Scholar] 79.Baranovich T, Saito R, Suzuki Y, et al