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The cysteine groups of SAM synthetase might be protected from oxidation by a normal concentration of GSH

doi: 10.1177/0961203318778368 84 HsiaoYHChenYTTsengCMWuLALinWCSuVYet al
Cremades N

In 2002, we compared the effect of the use of NEM with that of other commonly used alkylating agents and reported that both iodoacetic acid and monobromobimane slowly react with SH groups yielding too high values of GSSG

Blocking both xCT and GGCT synergistically depleted intracellular cysteine and GSH, leading to excessive accumulation of reactive oxygen species (ROS), lipid peroxidation, and ferroptotic cell death in glioblastoma cells

The role of the glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned patients