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Inhibition of Sphingolipid Synthesis as a Phenotype-Modifying Therapy in Cystic Fibrosis

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[DOI] [PubMed] [Google Scholar] 1371.Wildhirt SM, Weis M, Schulze C, Conrad N, Pehlivanli S, Rieder G, Enders G, von Scheidt W, Reichart B

To establish and validate the refolding screen, four different proteins were used: the receptor binding domain of hemagglutinin (HA-RBD), interleukin-17A (IL-17A), mouse double minute 2 homolog (MDM2) and the inhibitory receptor ligand of programmed death receptor 1 (PD-L1)

Memory CD8 + T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development

Prior to integrin-mediated ROS production, SLP-76 is required for the phosphorylation of PLC2 (Newbrough et al., 2003)