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AD patients often exhibit emotional changes, which are closely related to basal ganglia dysfunction (94)

The same review noted that the magnitude of the GH response declines with age once puberty has passed, a pattern shared with the endogenous GH axis itself

P.SuoP.RenL

Peak average serum IGF-1 levels during puberty are roughly around 380 ng/mL, and these levels sharply decline after puberty

10.1042/bst0311441 10 BetteridgeD

Lett 578 (2014) 1437