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679 Tert-butylhydroquinone (TBHQ), as an Nrf2 activator, has been shown to activate Nrf2-related pathways in a TBI mouse model by combining vanillin acetate and TBHQ, reducing oxidative stress and protecting gray matter in the mouse brain

In parallel, annotated metabolites were analyzed at the univariate level by using MetaboAnalyst 5.0 online software ( with unpaired two-sided nonparametric t -test 47

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