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Finally, further mechanistic research on CRIC is necessary

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(43) reported vitamin K3 (Menadione) through the suppression of NF-B and MAPK pathways, reducing macrophage-mediated inflammation, delaying graft-vs.-host disease (GVHD), and inhibiting CD4+ T-cell homeostatic proliferation modulates immune responses by altering cellular redox status, suppressing lymphocyte proliferation, and inhibiting T-cell activation and cytokine production showing potential as an immunosuppressive agent