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This mitochondrial destabilization is evidenced by significant CYTOCHROME C release, which is associated with the activation of the CASPASE cascade, as confirmed by elevated caspase-3 expression and activity

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Figure 3E) is an important natural active flavone, which is mainly extracted from the roots of Alpinia officinarum Hance, it has long been used as herbs and spices in South Africa and Asia (Yang et al., 2018)

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