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Administrated resveratrol positively affects the synthesis of sirtuins, SIRT1 (a family of proteins NAD + -dependent histone deacetylases playing an important role in the regulation of metabolic pathways, see below) activating then superoxide dismutase 2 (Mn-SOD) expression in cardiomyocytes and improved cardiac functions (Tanno et al

Mitophagy inhibits macrophage activation and thus immune defense, resulting in decreased pathogen clearance and infection, while inhibition of mitophagy in macrophages can promote macrophage activation and thus inhibit infection

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