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This association is evidenced by elevated serum levels of pro-inflammatory cytokines, such as interleukin-1 (IL-1), tumor necrosis factor (TNF-), IL-6, and IL-17

Retrospective reviews reported low response rates 178 or response similar to natural course of the disease 179

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Dextromethorphan, an oral alternative with additional activity at sigma1 and nicotinic receptors, has shown antiallodynic and antihyperalgesic effects in preclinical models