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Berberine from Coptis chinensis and baicalin from Radix scutellariae water extract can increase the population of bacteria with bile salt hydrolase activity (e.g., Lactobacillus ), thereby facilitating bile acid metabolism 117,118

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and the number of deaths from CVDs increased steadily from 12.1 million in 1990 to 18.6 million in 2019, accounting for 33% of all deaths globally (3)