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Spermatocyte-specific Gpx4 knockout mice were infertile [85]
In the event that this observation is corroborated in human subjects, a TRPC4 antagonist could potentially exhibit clinical efficacy in the treatment of addiction (Koivisto et al., 2022)
J Affect Disord 111:135144 Palta P, Samuel LJ, Miller ER 3rd, Szanton SL (2014) Depression and oxidative stress: results from a meta-analysis of observational studies
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These patients had all failed at least 1 year of standard treatment
They showed Mn overexposure reduced dopamine concentrations in the striatum, accompanied by impaired motor performance (Ivleva et al., 2022
