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They can cause significant muscle loss along with fat loss, which some research suggests may be as high as 30-40% of total weight lost

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Animal studies suggest that it reduces NNMT activity, leading to better NAD+ retention, improved metabolic efficiency, and reduced fat mass

Methods for Functional Characterization of FcRn Interactions with Therapeutic Antibodies and Fc-Fusion Proteins
Understanding these risk factors helps clinicians and patients make informed decisions about supplementation strategies